Tag: T4 RNA ligase
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Preferential production of RNA rings by T4 RNA ligase 2 without any splint through rational design of precursor strand
Circular single-stranded RNAs (C-RNAs) are RNA rings without terminals, which are promising for many practical applications both in vivo and in vitro. Recently, for example, thousands of circular RNAs (circRNAs) have been found almost in all kingdom of organisms, and their biological roles as miRNA or RNA inhibitors have been reported. Many circRNAs have also…