Tag: Reduction sensitive linkers (RSLs)
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A traceless linker for aliphatic aminesA traceless linker for aliphatic amines
Reduction sensitive linkers (RSLs) have the potential to transform the field of drug delivery due to their ease of use and selective cleavage in intracellular environments. However, despite their compelling attributes, developing reduction sensitive self-immolative linkers for aliphatic amines has been challenging due to their poor leaving group ability and high pKa values. Here a traceless […]