Tag: peptiligase variant
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Design of a substrate-tailored peptiligase variant for the efficient synthesis of thymosin-α1
The manufacture of long peptides using conventional chemical strategies is still very challenging and the technology used has remained almost unchanged since Merrifield developed the solid phase approach in the 1960s. Solid-phase peptide synthesis (SPPS) is characterized by an exponential decrease in the crude yield and purity as the peptide length increases: coupling and deprotection […]