February 23, 2024

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About Novelconjugates

Novel conjugates devoted to providing information about novel conjugates between amino acid/peptides and phytobioactive compounds with improved performance for scientific research and applications.

Amino acids are molecules specifically containing an amine group, a carboxylic acid group and a side-chain. Amino acids are the most important molecules in nature since they play key roles both as building blocks of proteins and as intermediates inmetabolism.The therapeutic applications of amino acids have received considerable attention in respiratory physiology, cardiology,renal failure, neurological disorders, and congenital defects.

Peptides and their derivatives exhibit a broad spectrum of biological activities such as antimicrobial, antiviral, anticancer activities, antiglycation, anti-inflammatory, antioxidants and also therapeutically most important in a broad range of areas including neurology, endocrinology and haematology.

Taking the advantage of low toxicity, biocompatibility and likeliness/structural diversity of amino acid residues with the biological system, currently there is huge tendency of conjugating amino acid/peptide residues with small bioactive heterocyclic motifs in the field of biomedical research. The conjugation of different amino acids/peptides to various biologically active heterocycles has fetched the outstanding results as are very promising drug candidates. Additionally, the amino acid/peptide based drugs have low toxicity, ample bioavailability and permeability, modest potency and good metabolic and pharmacokinetic properties.

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Phytocompounds

Phytocompounds used in cosmeceuticals include catechins, gallic acids, epicatechins, curcumin, hydroxylbenzoic and cinnamic acids, quercetin, ascorbic acids, luteolin, alpha and beta carotene, complex polysaccharides, and fatty acids.

Amino acids/Peptides

The conjugation of different amino acids/peptides to various biologically active phytocompounds has fetched the outstanding results as are very promising drug candidates.

Polymer

The ability of the thermoresponsive polymers to self-assemble allows for controlled aggregation of the bioconjugate molecules. Such aggregate formation opens novel routes to the biocarrier of controlled parameter.

Conjugation

Conjugation based on amide bond formation, used in the earliest works, has been supplemented with “click” chemistry, thiol‐maleimide reactions and several other methods, like oxime formation, Schiff base formation and “living” polymer chain end termination.

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