Chemical modification of nucleotides can improve the metabolic stability and target specificity of oligonucleotide therapeutics, and alkylphosphonates...
Nucleic Acids
Phosphorothioate-modified antisense oligonucleotides (PS-ASOs) interact with a host of plasma, cell-surface and intracellular proteins which govern their...
DNA is the fundamental genetic material of all living organisms on Earth that stores and propagates genetic...
Since phosphonic acid was found to be effective against fungal diseases, in particular those caused by oomycetes,...
The potential of oligonucleotide therapeutics is undeniable as more than 15 drugs have been approved to treat...
Activation of the p53 tumor suppressor can lead to cell cycle arrest. The key mechanism of p53-mediated...
The necessity for cellular regulation of DNA led to the development of metallonucleases to catalyze and repair...
G-quadruplexes (G4s) have long been implicated in the regulation of chromatin packaging and gene expression. These processes...
Peptide nucleic acids (PNAs) consist of an aminoethylglycine (aeg) backbone to which the nucleobases are linked through...
