Chemical modification of nucleotides can improve the metabolic stability and target specificity of oligonucleotide therapeutics, and alkylphosphonates...
rdpeptide
We provide information about bioconjugates and bioconjugation methods.
Phosphorothioate-modified antisense oligonucleotides (PS-ASOs) interact with a host of plasma, cell-surface and intracellular proteins which govern their...
Current strategies for delivery of macromolecules, such as nanoparticles, liposomes, viral-based vectors, microinjection, and electroporation (Kang et...
DNA is the fundamental genetic material of all living organisms on Earth that stores and propagates genetic...
Since phosphonic acid was found to be effective against fungal diseases, in particular those caused by oomycetes,...
The potential of oligonucleotide therapeutics is undeniable as more than 15 drugs have been approved to treat...
Incretins are hormones that are secreted from the gastrointestinal tract into the circulatory system in response to...
Activation of the p53 tumor suppressor can lead to cell cycle arrest. The key mechanism of p53-mediated...
The necessity for cellular regulation of DNA led to the development of metallonucleases to catalyze and repair...
G-quadruplexes (G4s) have long been implicated in the regulation of chromatin packaging and gene expression. These processes...