Solid phase reductive alkylation of secondary amines

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Solid phase reductive alkylation of secondary amines has been carried out in excellent yields using borane-pyridine complex (BAP). Various aldehydes and ketones have been reacted with L-proline substituted on high-capacity Wang Resin. (Tetrahedron Letters. Volume 37, Issue 27, 1 July 1996, Pages 4819-4822.)

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