Product name: Vasoactive intestinal peptide(VIP)
Synonym: Vasoactive intestinal polypeptide,VIP,HSDAVFTDNYTRLRKQMAVKKYLNSILN,
Uniprot ID: P01282
Catalog #: 3902013
CAS No.: 37221-79-7
Molecular Formula: C147H237N43O43S
Molecular Weight: 3326.83
Description: Vasoactive intestinal peptide (VIP) is a neuropeptide with known immunomodulatory properties on CD4 T cells that exert this action through specific receptors, vasoactive intestinal peptide receptor (VPAC)1 and VPAC2.Vasoactive Intestinal Peptide (VIP) decreases cell proliferation through PI3K signaling and prevents tumor progression in clear renal cell carcinoma (RCC). In the central and peripheral nervous system, vasoactive intestinal peptide (VIP), a 28-amino acid neuropeptide, is released to support neuronal survival in both physiological and pathological condition. VIP can inhibit the neurodegeneration induced by the loss of neurons. The indirect protection effect is mainly mediated by glial cells through the production of neurotrophic factor(s) and inhibition of proinflammatory mediators. By remolding the structure and improving the transfer efficiency of VIP, its nerve protective function could be further improved. Its neuroprotective action and efficacy in inhibiting a broad range of inflammatory responses make VIP or related peptides becoming a novel therapeutic method to neurodegenerative disorders (NDDs).