Product Name: Undecylenic acid-hLF1-11
Synonyms: UDA-GRRRRSVQWCA, Undecylenic acid-Gly-Arg-Arg-Arg-Arg-Ser-Val-Gln-Trp-Cys-Ala,
IUPAC Name: undec-10-enoylglycyl-L-arginyl-L-arginyl-L-arginyl-L-arginyl-L-seryl-L-valyl-L-glutaminyl-L-tryptophyl-L-cysteinyl-L-alanine,
Description: hLF1-11 is a short AMP with broad-spectrum activity comprising the eleven N-terminal amino acids 1–11 of human lactoferrin. Furthermore, hLF1-11 exerts modulatory effects on immune cells stimulating macrophages and dendritic cells, thus contributing to the clearance of infections. In addition, previous studies have shown that hLF1-11 has no cytotoxic effects against human erythrocytes, and its administration to healthy volunteers was well tolerated. Undecylenic acid (UDA), a naturally occurring 11-carbon unsaturated fatty acid, has been used for several years as an economical antifungal agent and a nutritional supplement. Moreover, one recent study revealed the anti-Candida mechanisms of action of UA, which reduces the hypha-to-yeast ratio and inhibits: hyphal formation, adhesion, mitochondrial activity, cell proliferation, transcriptional regulation of the cell membrane virulent factors, and biofilm formation.