Product Name: Undecylenic acid-Eugenol-IRW
Synonyms: Undecylenic acid-Eugenol-Ile-Arg-Trp,
IUPAC Name: ((E)-12-(4-hydroxy-3-methoxyphenyl)dodec-10-enoyl)-L-isoleucyl-L-arginyl-L-tryptophan,
Description: Eugenol (4-allyl-2-methoxyphenol) is a major component of clove oil and has been used as a flavoring agent in food and cosmetic products. Studies have shown that eugenol exhibits a number of potentially beneficial biological properties, including antimicrobial, antioxidant, anti-inflammatory, anticarminative, and antispasmodic activities. Recently, we demonstrated biofilm inhibition and eradication properties of eugenol against streptococci. Previous studies have also demonstrated that eugenol can disrupt the cell membrane of Salmonella typhi, and decreases toxin-related gene expression of S. aureus at sub-inhibitory concentrations. Undecylenic acid (UDA), a naturally occurring 11-carbon unsaturated fatty acid, has been used for several years as an economical antifungal agent and a nutritional supplement. Moreover, one recent study revealed the anti-Candida mechanisms of action of UA, which reduces the hypha-to-yeast ratio and inhibits: hyphal formation, adhesion, mitochondrial activity, cell proliferation, transcriptional regulation of the cell membrane virulent factors, and biofilm formation. The egg-derived tripeptide IRW has shown promise in controlling both the hyperactive renin-angiotensin system (RAS) pathway as well as the exaggerated proinflammatory phenotype in spontaneously hypertensive rats (SHRs), a widely used model of hypertension and cardiovascular disease.