Description

Product name: Sweet Arrow Peptide (SAP)

Synonym: VRLPPPVRLPPPVRLPPP,

Sequence: Val-Arg-Leu-Pro-Pro-Pro-Val-Arg-Leu-Pro-Pro-Pro-Val-Arg-Leu-Pro-Pro-Pro

IUPAC Name:

Catalog #: 3904062

CAS No.: N/A

Molecular Formula: C96H161N27O19

Molecular Weight: 1997.51

Description: Sweet Arrow Peptide (SAP) has a Pro-rich structure and is derived from the N-terminal domain of γ-zein, a maize storage protein.  (VXLPPP)n is a new family of peptides that can translocate human cell membranes. Compared with other carrier peptides, this new family presents several advantages including its nonviral origin, amphipathic character, solubility in water, and the absence of a cytotoxic effect at high concentrations, both in vitro and in vivo.  It is noteworthy to mention that SAP retains a PPII conformation if 50% of the sequence remains as proline, forming a left-handed helix of 3.0 residues per turn, which affords three distinct ‘faces’ in aqueous solution, Consequently, spatial parameters of the BBB shuttle could be readily studied through simple mutation of valine, arginine, or leucine amino acids to orthogonal residues at specific sites.

 

Usage: For Scientific Research Use Only, Not for Human Use.

 

Reference:

Angewandte Chemie International Edition, 43(14), 1811–1814.

Chem Sci. 2019 Dec 14; 10(46): 10772–10778.