Product name: SS31
Synonym: Elamipretide, Bendavia, H-D-Arg-Tyr(2,6-diMe)-Lys-Phe-NH2, H-D-Arg-Dmt-Lys-Phe-NH2,
IUPAC Name: (2S)-6-amino-2-[[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]hexanamide,
Catalog #: 3902004
CAS No.: 736992-21-5
Molecular Formula: C32H49N9O5
Molecular Weight: 639.80
Description: SS31 is a tetra-peptide, cell-permeable, mitochondria-targeted molecule. The SS31 is one of the four molecules (SS31, SS02, SS19, SS20) developed by Szeto and Schiller that is capable of targeting and permeating to mitochondria. The chemical structure of SS31 is H-D-Arg-Dmt-Lys-Phe-NH2, and its structural motif centers on alternating aromatic residues and basic amino acids. SS31 has a sequence motif that allows it to target mitochondria, scavenge free radicals, including H2O2 and ONOO−, and inhibit lipid peroxidation. Its capability of protecting to be attributed to tyrosine, or dimethyltyrosine, a residue that scavenges oxyradicals and forms relatively unreactive tyrosyl radicals. The unreactive tyrosyl radicals trigger the coupling of tyrosyl radicals to each other, giving rise to dityrosine, which reacts with a superoxide to form tyrosine hydroperoxide. Recently, the efficacy of SS31 was studied in rodent models of ischemic brain injury, diabetes, myocardial infarction and amyotrophic lateral sclerosis (ALS). These researchers found that SS31 protects cells from mitochondrial toxicity in all of these disease states. SS-31 represents a novel platform of mitochondria-targeted antioxidants with broad therapeutic potential.