Skin penetrating peptide TD-1

$500.00

Quantity: 25mg

Description

Product name: TD-1

Synonyms: ACSSSPSKHCG,

Sequence: Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly (disulfide)

IUPAC Name:

Catalog #: 3904011

CAS No.: —

Molecular Formula: C40H64N14O16S2

Molecular Weight: 1061.15

Description: Here, we show that a synthetic peptide, TD (ACSSSPSKHCG) was efficient in transferring human growth hormone (GH) across various kinds of membranes and the blood-brain barrier (BBB) in vivo via rectal administration, resulting in elevation of GH level in serum, acetylcholine and O-choline acetyltransferase activities and GH /IGF-1 contents in brain tissues, manifesting great therapeutic effects on chronic age-related dementia in mice and ameliorating neuronal damage in the brain. A highly hydrophilic [Cys-Cys] cyclic 11-mer peptide that facilitates transdermal protein drug delivery by creating a transient opening in the skin barrier. Topical coadministration of TD-1 has been shown to enable insulin and human growth hormone to reach systemic circulation in rats in vivo.

 

Usage: For Scientific Research Use Only, Not for Human Use.

 

Reference:

J Pharm Sci. 2010 Dec;99(12):4880-91.

Nat Biotechnol. 2006 Apr;24(4):455-60.

Additional information

Purity

95%

Package size

25mg

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