Product name: TD-1
Sequence: Ala-Cys-Ser-Ser-Ser-Pro-Ser-Lys-His-Cys-Gly (disulfide)
Catalog #: 3904011
CAS No.: —
Molecular Formula: C40H64N14O16S2
Molecular Weight: 1061.15
Description: Here, we show that a synthetic peptide, TD (ACSSSPSKHCG) was efficient in transferring human growth hormone (GH) across various kinds of membranes and the blood-brain barrier (BBB) in vivo via rectal administration, resulting in elevation of GH level in serum, acetylcholine and O-choline acetyltransferase activities and GH /IGF-1 contents in brain tissues, manifesting great therapeutic effects on chronic age-related dementia in mice and ameliorating neuronal damage in the brain. A highly hydrophilic [Cys-Cys] cyclic 11-mer peptide that facilitates transdermal protein drug delivery by creating a transient opening in the skin barrier. Topical coadministration of TD-1 has been shown to enable insulin and human growth hormone to reach systemic circulation in rats in vivo.
Usage: For Scientific Research Use Only, Not for Human Use.
J Pharm Sci. 2010 Dec;99(12):4880-91.
Nat Biotechnol. 2006 Apr;24(4):455-60.