Product name: PNC27
Synonyms: p53 12–26-leader,p53-derived peptide, PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG,
Catalog #: 3904001
CAS No.: —
Molecular Formula: C188H293N53O44S
Molecular Weight: 4031.7
Description: The PNC27 peptide comprises the mdm-2 binding domain of the p53 protein (residues 12–26) containing a C-terminal Penetratin sequence as carrier (PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG). Unexpectedly, this peptide was found to induce selective necrosis in various carcinogenic cell types, as it has an amphipatic structure which allows it to integrate into the cell membrane forming pores, producing membrane disruption and cell death by a p53-independent mechanism. The selectivity on tumor cells would be given by the presence of mdm-2 on the plasma membrane of these cells, which is related to the role of mdm-2 in E-cadherin ubiquitination and degradation. Thus, in non-tumor cells, PNC27 enters the cell, but in cancer cells it is retained in the membrane due to its affinity for mdm-2, and forms pores.