Product name: Peptide shuttle (HAI)
IUPAC Name: (S)-1-(L-histidyl-L-arginyl)-N-((S)-1-(((2S,3S)-1-(((S)-1-(((S)-1-amino-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)pyrrolidine-2-carboxamide,
Catalog #: 3904059
CAS No.: N/A
Molecular Formula: C41H61N15O8
Molecular Weight: 892.04
Description: Peptide HAI was found by Lee et al. by phage display against the human transferrin receptor (TfR). Highly expressed in brain capillaries, TfR mediates the delivery of iron to the brain. It is also expressed in choroid plexus epithelial cells and neurons. One of the main advantages of this peptide is that it interacts in a region of the TfR that does not overlap with the native binding site of transferrin, thereby avoiding physiological effects on the protein function in vivo and consequently making this peptide very attractive from the therapeutic point of view. HAI has been studied for diverse applications such as tumor-targeting and oral drug delivery. Its potential as a BBB shuttle has recently been addressed by Kuang et al.. Given that other peptides interacting with the TfR have the capacity to cross the BBB10 and that the BBB endothelium is characterized by high presence of TfR—a feature that can selectively enhance brain targeting—here we expand on the potential applications of HAI as a BBB shuttle.
Usage: For Scientific Research Use Only, Not for Human Use.
Sci Rep. 2018; 8: 17932.