iRGD

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$600.00

Nuoro Quantity: 50mg

Description

http://karen-keogh.co.uk/portfolio/distant-olive-grove/ Product name: iRGD

buy Lyrica 50 mg Synonym: CRGDKGPDC,

Sequence: Cys-Arg-Gly-Asp-Lys-Gly-Pro-Asp-Cys

IUPAC Name:

Catalog #: 3904037

CAS No.: 1392278-76-0

Molecular Formula: C35H57N13O14S2

Molecular Weight: 948.04

Description: Tumor-penetrating peptides are a class of tumor-homing peptides capable of delivering both covalently coupled and co-administered drug payloads deep into tumor tissue. The drugs targeted with iRGD include conventional chemotherapeutics (doxorubicin, gemcitabine), tyrosine kinase inhibitors, anti-tumor antibodies, and nanoparticle drugs, and the tumor models used range from subcutaneous and orthotopic tumors, both syngeneic transplantable and xenografts. Nanoparticle-coupled iRGD is more effective in inhibiting metastasis than an equivalent amount of free iRGD peptide. The new peptide, iRGD, was identified in a screen for peptides that home to tumor metastases. It is a 9-amino acid cyclic peptide (sequence: CRGDKGPDC). iRGD has the integrin-binding RGD motif, but it was immediately obvious to us that this peptide was different from standard RGD peptides; the iRGD phage and the free iRGD peptide spread much more extensively into extravascular tumor tissue than other RGD peptides, which tend to accumulate only around tumor vessels. the Tumor-penetrating peptides are a class of tumor-homing peptides capable of delivering both covalently coupled and co-administered drug payloads deep into tumor tissue. The drugs targeted with iRGD include conventional chemotherapeutics (doxorubicin, gemcitabine), tyrosine kinase inhibitors, anti-tumor antibodies, and nanoparticle drugs, and the tumor models used range from subcutaneous and orthotopic tumors, both syngeneic transplantable and xenografts. Nanoparticle-coupled iRGD is more effective in inhibiting metastasis than an equivalent amount of free iRGD peptide. The new peptide, iRGD, was identified in a screen for peptides that home to tumor metastases. It is a 9-amino acid cyclic peptide (sequence: CRGDKGPDC). iRGD has the integrin-binding RGD motif, but it was immediately obvious to us that this peptide was different from standard RGD peptides; the iRGD phage and the free iRGD peptide spread much more extensively into extravascular tumor tissue than other RGD peptides, which tend to accumulate only around tumor vessels. CendR motif (R/KXXR/K) binds to neuropilin-1 (NRP-1) or neuropilin-2 (NRP-2), and the interaction activates an endocytotic/exocytotic transport pathway named the CendR pathway. This pathway is responsible for the enhanced transport of drugs into tumors triggered by iRGD.

Usage: For Scientific Research Use Only, Not for Human Use.

 Reference:

Adv Drug Deliv Rev. 2017 Feb; 110-111: 3–12.

 

Additional information

Purity

95%

Package size

25mg

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