Quantity: 25mg

SKU: 3219001 Category: Tag:


Product Name: Idebenone-Angiopep-2(Carbamate)

Synonyms: Idebenone-TFFYGGSRGKRNNFKTEEY, Idebenone-Thr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-Tyr-OH,

Cat#: 3219001

M.F.: C124H177N29O37

M.W.: 2665.95

Description: Angiopep-2, a 19-amino-acid peptide (TFFYGGSRGKRNNFKTEEY-OH), by sequence alignment of aprotinin and other LRP1-binding proteins harboring a Kunitz-type domain. Angiopep-2 was shown to cross the BBB, and its conjugate with paclitaxel (ANG1005) is now in Phase II study for the treatment of recurrent brain metastases of pretreated breast cancer patients. Idebenone has been reported to improve energetic metabolism deficiencies and to relieve neurologic symptoms. Initially developed for the treatment of cognitive disturbances and Alzheimer’s disease, idebenone is approved as an orphan drug by the Food Drug and Administration (FDA) and European agencies for the treatments of Friedreich’s ataxia, Leber’s hereditary optic neuropathy, or Duchenne muscular dystrophy.

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