Product name: Hyaluronic acid-Leu-Leu-Leu-Oet
Molecular Weight: 1000-1500Kdal
Peptide Content: 1.0%-10.0%
Format: White to slight yellow solid
Description: Hyaluronic acid (HA), also named hyaluronan, is a high molecular weight (105–107 Da) naturally occurring biodegradable polymer. HA is an unbranched non-sulfated glycosaminoglycan (GAG) composed of repeating disaccharides (β-1,4-D-glucuronic acid (known as uronic acid) and β-1,3-N-acetyl-D-glucosamide). Hyaluronic acid is one of the major elements in the extracellular matrix (ECM) of vertebrate tissues. It is available in almost all body fluids and tissues, such as the synovial fluid, the vitreous humor of the eye, and hyaline cartilage. Trileucine-containing particles are corrugated, owing to trileucine’s low aqueous solubility. This result in significantly improved aerosol performance. However, corrugation is not the only factor for improving aerosol performance, which seems to be also influenced by the low surface energy, noncohesive nature of trileucine particles, which is a reflection of its surface activity in solution. Finally, peptide and protein aggregation and chemical degradation (deamidation and hydrolysis) can be reduced by the addition of trileucine in the formulation, presumably related to trileucine surface activity in solution.