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Quantity: 25mg

SKU: 3301035 Category: Tag:


Product Name: Ergosterol-Spermine(Carbamate)

IUPAC Name: (3S,9S,10R,13R,14R)-17-((E)-5,6-dimethylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl (3-((4-((3-aminopropyl)amino)butyl)amino)propyl)carbamate,

Cat#: 3301035

M.F.: C39H68N4O2

M.W.: 625.00

Description: Ergosterol (Erg), a prominent phytosterol, has also shown anti-tumor and anti-angiogenic activities with promising prospects in both in vitro and in vivo studies. The ergosterol is now seen as a strong drug candidate with no side effects and has the potential to induce cancer cell death. However, the poor aqueous solubility of the sterol has hindered its wider clinical applications. Polyamines, such as putrescine, spermidine, and spermine (SPM), are aliphatic cations that interact with nucleic acids and proteins, functioning as modulators for cell growth, cell differentiation, and synthesis of DNA, RNA, and proteins. Polyamines are catabolized by back-conversion through acetylation and oxidation mediated by spermidine/spermine N1-acetyltransferase (SSAT) and N′-acetylpolyamine oxidase (APAO), respectively, or oxidation of SPM by SPM oxidase (SMO). Dysregulation of polyamine metabolism is frequently associated with cancer and other hyperproliferative diseases.

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