Product Name: Camphanediol-Tetrapeptide-3
Description: Bicyclic monoterpene diols (BMTd) stimulate nitric oxide synthesis in melanoma and neuronal cells, representing cell types arising from embryonic neural crest tissue. This study shows that an equimolar mixture of the BMTd’s 2,3-cis/exo-pinanediol and 2,3-cis/exo-camphanediol stimulates nitric oxide synthesis in epithelial cells of the skin, specifically normal human epidermal keratinocytes (NHEK) and normal human microvascular endothelial cells (HMVEC). These results show that a mixture of BMTd’s increases nitric oxide, and application to skin increases microcirculation and skin temperature. SPARC proteolytic fragment KGHK peptide, a Cu2+-binding sequence, stimulate the formation of endothelial cell networks in a luteal cell culture system (P<0.05) and increased progesterone production (P<0.05). Treatment with the proteolytic fragment of SPARC (KGHK) promoted the formation of luteal endothelial cell networks and surprisingly it also increased progesterone production. The peptide has a direct effect on hair follicle. The remodeling signal will increase the size of hair follicle for better hair anchoring and vitality.