Betulinic acid-Yamamarin

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Quantity: 25mg

SKU: 3205012 Category: Tag:


Product Name: Betulinic acid-Yamamarin

Synonyms: Betulinic acid-DILRG-NH2, Betulinic acid-Asp-Ile-Leu-Arg-Gly-NH2,

IUPAC Name: (6S,9S,12S,15S)-1-amino-6-((2-amino-2-oxoethyl)carbamoyl)-12-((S)-sec-butyl)-15-((1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysene-3a-carboxamido)-1-imino-9-isobutyl-8,11,14-trioxo-2,7,10,13-tetraazaheptadecan-17-oic acid,

Cat#: 3205012

M.F.: C54H91N9O9

M.W.: 1010.38

Description: Betulinic acid is capable of inducing apoptosis in tumor cells of certain types such as melanoma, lung cancer, ovarian cancer and neuroectodermal tumors. Betulinic acid stimulates apoptosis with the participation of reactive oxygen species (ROS). ROS contribute to permeabilization of the outer mitochondrial membrane (OMM), releasing apoptogenic mitochondrial proteins (cytochrome c, Smac, apoptosis inducing factor (AIF)) from the intermembrane space, and subsequent activation of the caspase cascade. Yamamarin, a pentapeptide with an amidated C-terminus (DILRG-NH(2)) isolated from larvae of the silkmoth,suppressed proliferation of rat hepatoma (liver cancer) cells.

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