Product Name: Azelaic acid-Glucosamine
IUPAC Name: 9-oxo-9-(((2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl)amino)nonanoic acid,
Description: Naturally occurring as a dicarboxylic acid isolate from the organism responsible for Pityriasis versicolor, azelaic acid (AA) has been shown to be effective in the treatment of Postinflammatory hyperpigmentation (PIH). AA has several mechanisms by which it depigments the skin including tyrosinase inhibition as well as selective cytotoxic and antiproliferative effects toward abnormal melanocytes through the inhibition of DNA synthesis and mitochondrial enzymes. Glucosamine is an aminosaccharide, acting as a preferred substrate for the biosynthesis of glycosaminoglycan chains and, subsequently, for the production of aggrecan and other proteoglycans of cartilage. Glucosamine exerts immunosuppressive effects on IL-2-mediated T cell proliferation and cytokine secretion in the mixed-lymphocyte reaction (MLR). Glucosamine negatively regulates both Th1/Th17-mediated autoimmune encephalomyelitis (EAE) and Th2-dominant atopic dermatitis in vivo.