Product Name: Asiatic acid-Taurine
IUPAC Name: 2-((1S,2R,4aS,6aS,6bR,8aS,9S,11R,12aR,12bS,14bS)-8a,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxamido)ethane-1-sulfonic acid,
Description: Taurine (2-aminoethane- sulfonic acid), an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine is one of the most abundant amino acids in the brain and spinal cord, leukocytes, heart and muscle cells, the retina, and indeed almost every tissue throughout the body. There is ever-increasing evidence that taurine depletion leads to a wide range of pathological conditions, including severe cardiomyopathy, renal dysfunction, pancreatic β cell malfunction, and loss of retinal photoreceptor.Numerous studies have indicated that taurine plays a significant role in overcoming insulin resistance and other risk factors in animal models of Type 1 and Type 2 diabetes. More specifically, taurine administration has been shown to prevent high glucose-induced microangiopathy, i.e., vascular endothelial cell apoptosis, and in fructose-fed rats, it has been found to restore glucose metabolizing enzyme activities and improve insulin sensitivity by modifying the postreceptor events of insulin action. Asiatic acid (AsA) is a pentacyclic triterpenoid derived from the tropical medicinal plant Centella asiatica (family-Apiaceae). Beneficial effects of AsA have been reported in wound healing, UV-induced photoaging, glutamate- or β-amyloid-induced neurotoxicity and hepatofibrosis. Furthermore, there are numerous reports suggesting the strong neuroprotective and anti-cancer efficacy of AsA. For example, AsA treatment has been reported to induce apoptotic death in human hepatoma and malignant glioma cells through enhancing the intracellular calcium release.