buy ivermectin europe Product name: Angiopep-2
Bom Conselho Synonyms: TFFYGGSRGKRNNFKTEEY,
Catalog #: 3904029
CAS No.: —
Molecular Formula: C104H149N29O31
Molecular Weight: 2301.51
Description: Absorptive- and receptor-mediated transcytosis (AMT/RMT) are widely studied strategies to deliver therapeutics across the blood-brain barrier (BBB). To enable targeted brain delivery, we chose to functionalise our scaffold with established ligands that engage the transferrin receptor (TfR) and low-density lipoprotein-receptor related protein (LRP1). The relative abundance of these receptors on brain endothelial, alongside their high transport capacity, made them ideal targets for RMT mediated delivery and both have been actively explored in research. Angiopep-2, which is a 19-mer peptide derived from human Kunitz domain, can trigger transcytosis and traverse the BBB by recognizing low density lipoprotein-related protein 1 (LRP-1) expressed on the brain capillary endothelial cells. While less is known about trafficking of LRP1, APep2-conjugates have shown demonstrable success in clinical trials of neurological disease models. Recent investigations with retro-enantio sequences of both TfRL1 and APep2 have shown that metabolic limitations can be overcome without the loss of function, offering a plausible solution to degradation.
Usage: For Scientific Research Use Only, Not for Human Use.