gen-casino-it Product Name: 10-HAD-YIGSR
Svobody Synonyms: 10-hydroxy-2-decenoic acid-Tyr-Ile-Gly-Ser-Arg,
IUPAC Name: 10-hydroxydec-2-enoyl)-L-tyrosyl-L-isoleucylglycyl-L-seryl-L-arginine,
Description: 10-hydroxy-2-decenoic acid (10-HDA),with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, and anti-aging activities, has been shown to increase collagen synthesis and production of the collagen promoting factor, transforming growth factor β1, in human skin fibroblasts. Such an effect is thought to mediate royal jelly skin protection against UVB-induced photoaging. The laminin tyrosine-isoleucine-glycine-serine-arginine (YIGSR) peptide, corresponding to the 929–933 sequence of the β1 chain, is known to be a functional motif with effects on the inhibition of tumor metastasis, the regulation of sensory axonal response and the inhibition of angiogenesis through high affinity to the 67 kDa laminin receptor. YIGSR peptide to enhance collagen synthesis in human dermal fibroblasts.YIGSR peptide strongly enhanced collagen type 1 synthesis without changing cell proliferation or cellular MMP-1 level. This YIGSR peptide plays a novel function on the collagen type 1 synthesis of dermal fibroblasts and also suggests that YIGSR is a strong candidate peptide for the treatment of skin aging and wrinkles.