Polyamine conjugates

Polyamines (spermidine, putrescine and spermine) are multifunctional polycationic aliphatic amines, which serve crucial roles in cell survival. Besides serving as nutrients and metabolic regulators, polyamines have been implicated as mediators of key cell functions, such as proliferation, migration and differentiation. Polyamines also stabilize DNA/RNA and modulate DNA replication/transcription, and stabilize membrane and cytoskeletal proteins. Dysregulation of cellular polyamines is associated with various pathological conditions, including cancer, and polyamine pathways have been explored as targets for cancer chemotherapy and chemoprevention.